gliotoxin การใช้

• LaeA and GliZ are transcription factors known to regulate the production of gliotoxin.
• It also acts as a neurotoxin, gliotoxin, proinflammatory mediator, and pro-oxidant molecule.
• The production of numerous secondary metabolites, including gliotoxin, were impaired in an LaeA mutant ( ?laeA ) strain.
• "A . fumigatus " grown on certain building materials can produce genotoxic and cytotoxic mycotoxins, such as gliotoxin.
• LaeA regulated toxins, besides gliotoxin, likely have a role in virulence since loss of gliotoxin production alone did not recapitulate the hypo-virulent  " laeA pathotype.
• LaeA regulated toxins, besides gliotoxin, likely have a role in virulence since loss of gliotoxin production alone did not recapitulate the hypo-virulent  " laeA pathotype.
• Aflatoxin B1 is the most toxic and potent hepatocarcinogenic natural compound characterized . " A . flavus " also produces other toxic compounds including sterigmatocystin, cyclopiazonic acid, kojic acid, ?-nitropropionic acid, aspertoxin, aflatrem, gliotoxin, and aspergillic acid.
• "A . terreus " produces a number of secondary metabolites and mycotoxins, including territrem A, citreoviridin, citrinin, gliotoxin, patulin, terrein, terreic acid, and terretonin . " A . terreus " strains use glycerol and glucose as their best carbon sources for lovastatin production.