hmg14 การใช้

• NBP-45 is a nucleosomal binding protein, first identified in mice, which is related to HMG14 and HMG17.
• These findings led to the suggestion that this domain, common to NBP-45, HMG14 and HMG17 is responsible for binding of the proteins to nucleosomes in chromatin.
• Chromosomal protein HMG14 and its close analog HMG17 ( MIM 163910 ) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer.
• HMG14 and HMG17 are highly-similar proteins of about 100 amino acid residues; the sequence of chicken HMG14 is almost as similar to chicken HMG17 as it is to mammalian HMG14 polypeptides.
• HMG14 and HMG17 are highly-similar proteins of about 100 amino acid residues; the sequence of chicken HMG14 is almost as similar to chicken HMG17 as it is to mammalian HMG14 polypeptides.
• HMG14 and HMG17 are highly-similar proteins of about 100 amino acid residues; the sequence of chicken HMG14 is almost as similar to chicken HMG17 as it is to mammalian HMG14 polypeptides.
• The domain is most commonly found in the high mobility group ( HMG ) proteins, HMG14 and HMG17, however, it is also found in other proteins which bind to nucleosomes, e . g.
• Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.