homotropic การใช้

• For example, O 2 and CO are homotropic allosteric modulators of hemoglobin.
• The relaxation of gastrointestinal tract motility is by presynaptic inhibition, where transmitters inhibit further release by homotropic effects.
• A homotropic allosteric modulator is a substrate for its target enzyme, as well as a regulatory molecule of the enzyme's activity.
• In the case of hemoglobin, Bohr observed homotropic positive cooperativity ( binding of oxygen facilitates binding of more oxygen ) and heterotropic negative cooperativity ( binding of CO 2 reduces hemoglobin's facility to bind oxygen .)
• A mutant that had this residue mutated to alanine showed a huge reduction in specific activity, a two-fold decrease in the affinity for aspartate, a loss of homotropic cooperativity, and decreased activation by ATP . It was suggested that the change in the overall structure caused by the introduction of this residue affects other residues in the R1-C1, R1-C4 and C1-C4 interfaces, which are involved in the quaternary structure transition.