igg2a การใช้

• The combination of this cytokine and IL12 has been shown to inhibit IgG1 production, and enhance IgG2a production in B cells.
• In a mouse model of autoantibody mediated anemia using IgG isotype switch variants of an anti erythrocytes autoantibody, it was found that mouse IgG2a was superior to IgG1 in activating complement.
• This allows the toxin to promote immunological responses such as IgG2a, IgA, and Th17 to fight for instance gastric " Helicobacter pylori " infection when a vaccine is given.
• Moreover, it was found that the IgG2a isotype was able to interact very efficiently with FcgammaR . As a result, 20 times higher doses of IgG1, in relationship to IgG2a autoantibodies, were required to induce autoantibody mediated pathology.
• Moreover, it was found that the IgG2a isotype was able to interact very efficiently with FcgammaR . As a result, 20 times higher doses of IgG1, in relationship to IgG2a autoantibodies, were required to induce autoantibody mediated pathology.
• The CD79a ITAM tyrosine phosphorylation and signaling is negatively regulated by serine and threonine residues in direct proximity of the ITAM ( human CD79a Ser197, Ser203, Thr209; mouse CD79a Ser191, Ser197, Thr203 ), and play a role in limiting formation of bone marrow plasma cells secreting IgG2a and IgG2b.