isosteric การใช้

• *Procainamide, an amide, has a longer duration of action than Procaine, an ester, because of the isosteric replacement of the ester oxygen with a nitrogen atom.
• First, in the case of the diaryl system "'9 "', relatively high stereoselectively is achieved despite the isosteric nature of the ketone substituents, suggesting that electronics in addition to sterics may play a role in the stereoselectivity of the CBS reduction.
• One approach is the design of soft drugs ( SDs ), new, active therapeutic agents, often isosteric or isolelectronic analogs of a lead compound, with a chemical structure specifically designed to allow predictable metabolism into inactive metabolites after exerting their desired therapeutic effect ( s ).