lipofuscin การใช้

• A tetrahydropyridoether can remove lipofuscin from retinal pigment epithelial cells.
• The brown pigment is lipofuscin in macrophages, not melanin.
• Damaged proteins and lipids accumulate in lysosomes as lipofuscin.
• Some neurodegenerative disorders have been associated with lipofuscin accumulation.
• Accumulation of lipofuscin in the colon is the cause of the condition melanosis coli.
• When the skin is aged, some aged cells that contain lipofuscin bodies cannot be removed.
• By a feedback loop, more and more neighbor cells become aged and lipofuscin-containing.
• The dense lipofuscin bodies in the capsule make a protruding spot soft and dark in color.
• The nootropic drug piracetam appears to significantly reduce accumulation of lipofuscin in the brain tissue of rats.
• Pathologically the ceroid-lipofuscin accumulates mainly in neurons and contains subunit C of the mitochondrial ATP synthase.
• Successive encapsulation of dead cells and lipofuscin bodies results in the growth of a spot in three dimensions.
• This ability to selectively target lipofuscin has opened up research opportunities in the field of Anti-aging medicine.
• Vitelliform macular dystrophy causes a fatty yellow pigment ( lipofuscin ) to build up in cells underlying the macula.
• However, this result is controversial, as it is questionable if the leupeptin-induced material is true lipofuscin.
• In humans, yellowish specks or patches are thought to be due to the pigment lipofuscin, also known as lipochrome.
• Research at the preclinical ( animal ) stage include a new compound that can remove lipofuscin from retinal pigment epithelial cells.
• Isolation of the un-digestible lipofuscin bodies in a fibrotic capsule is essential for maintaining the structural integrity of the tissue.
• Researchers have not determined how these malfunctioning channels are related to the buildup of lipofuscin in the macula and progressive vision loss.
• Those molecules which can t be digested accumulate as junk inside our cells, which is detected in the form of lipofuscin granules.
• Secondly, protruding of a flat spot is a result of the death of aged cells in the spot and release of lipofuscin bodies.