mannoheptulose การใช้

• Examples of heptoses include the ketose s mannoheptulose and sedoheptulose.
• Mannoheptulose has been reported to inhibit insulin secretion from pancreas.
• It is found as D-mannoheptulose in avocados.
• Experiments with rats have indicated that D-mannoheptulose injections created an aversion to carbohydrates.
• However, while mannoheptulose is suggested to affect the energy balance of adult dogs, independent of dosage and physical activity, research disagrees whether it significantly alters energy expenditure in dogs.
• This inhibition occurs because when mannoheptulose is present the glycolysis is inhibited ( because there is no production of glucose-6-P ) therefore no increase in ATP concentration which is required to close the KATP channel in the beta cells of the pancreas causing a diminution of calcium entry and insulin secretion.