mastocyte การใช้

• Interaction with SP receptors induces vasodilation and allows for plasma extravasation and mastocyte degranulation.
• The process of acute inflammation is initiated by cells already present in all tissues, mainly resident macrophages, dendritic cells, histiocytes, Kupffer cells, and mastocytes.
• Upon contact with PAMPs, tissue macrophages and mastocytes release vasoactive amines such as histamine and serotonin, as well as eicosanoids such as prostaglandin E2 and leukotriene B4 to remodel the local vasculature.
• Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events : adhesion, emigration, chemotaxis, phagocytosis, respiratory burst, and the release of various inflammatory mediators ( lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines, etc . ) from neutrophils, macrophages, and mastocytes.