megakaryocytes การใช้

• Thrombopoietin stimulates megakaryopoiesis, the process of megakaryocyte maturation and differentiation.
• The development of megakaryocytes is in turn governed by two protein hormones.
• The cell eventually reaches megakaryocyte stage and loses its ability to divide.
• It drives red blood cell differentiation and represses megakaryocyte formation.
• Platelets are derived from blood cells known as megakaryocytes.
• It's known as megakaryocyte growth and development factor, or MGDF.
• Macrophages remove senescent erythrocytes, leukocytes, and megakaryocytes by phagocytosis and digestion.
• In megakaryocytes, it is regulated by the GATA-1 transcription factor.
• Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation.
• Both early and late in disease, megakaryocytes are often prominent and are usually dysplastic.
• It is also expressed in hematopoietic progenitor cells including erythroblasts, myeloblasts, and megakaryocytes.
• Immunophenotyping using MoAb to megakaryocyte restricted antigen ( CD41 and CD61 ) may be diagnostic.
• On the other hand, high platelet concentrations lead to less availability of thrombopoietin to megakaryocytes.
• The abnormal megakaryocytes stimulate other cells, the fibroblasts, to produce collagen in the bone marrow.
• P-selectin is constitutively expressed in megakaryocytes ( the precursor of platelets ) and endothelial cells.
• GATA1 is required for the maturation of red blood cells, megakaryocytes, mast cells and eosinophils.
• It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation.
• LOX expression was also detected in megakaryocytes, or bone marrow cells responsible for the production of platelets.
• SCF also increases the survival of various hematopoietic progenitor cells, such as megakaryocyte progenitors, in vitro.
• VIP acts in an autocrine fashion via VPAC 1 1 to inhibit megakaryocyte proliferation and induce proplatelet formation.