megalin การใช้

• The first is defining trafficking and signaling mechanisms of megalin.
• LRP2 gene mutations that cause Donnai Barrow syndrome are believed to result in the absence of functional megalin protein.
• Megalin is embedded in the membrane of cells that line the surfaces and cavities of the body ( epithelial cells ).
• The lack of functional megalin in the renal tubules causes megalin's various ligands to be excreted in the urine rather than being absorbed back into the bloodstream.
• The lack of functional megalin in the renal tubules causes megalin's various ligands to be excreted in the urine rather than being absorbed back into the bloodstream.
• The features of Donnai Barrow syndrome are probably caused by the inability of megalin to help absorb these ligands, disruption of biochemical signaling pathways, or other effects of the nonfunctional megalin protein.
• The features of Donnai Barrow syndrome are probably caused by the inability of megalin to help absorb these ligands, disruption of biochemical signaling pathways, or other effects of the nonfunctional megalin protein.