megaloblasts การใช้

• He demonstrated the existence of nucleated red blood cells, which he subdivided into normoblasts, megaloblasts, microblasts and poikiloblasts; he had discovered the precursors of erythrocytes.
• Nucleated red blood cells in mammals consist of two forms : normoblasts, which are normal erythropoietic precursors to mature red blood cells, and megaloblasts, which are abnormally large precursors that occur in megaloblastic anemias.
• Classically, these megaloblastic types of anemias are associated also with more specific features, such as megaloblasts in the bone marrow, the presence of ovalocytes in the ( peripheral ) blood smear, and the pathognomonic presence of hypersegmented neutrophils.
• The pathological state of megaloblastosis is characterized by many large immature and dysfunctional red blood cells ( megaloblasts ) in the bone marrow and also by hypersegmented neutrophils ( those exhibiting five or more nuclear lobes ( " segments " ), with up to four lobes being normal ).