melanoblast การใช้

• Conditions associated with abnormalities in the migration of melanoblasts are known collectively as piebaldism.
• In melanogenesis, melanoblasts migrate from the neural crest to their appropriate locations in the epidermis.
• Like for melanoblasts, this helps guide the cells to their appropriate locations in the body.
• Melanocyte stem cells are called melanoblasts.
• Melanoblasts express the KIT receptor, and it is believed that SCF guides these cells to their terminal locations.
• The resulting pattern appears symmetrical only if melanoblasts migrate to both locations of a pair and proliferate to the same degree in both locations.
• Location of the pigmented spots is dependent on the migration of melanoblasts ( primordial pigment cells ) from the neural crest to paired bilateral locations in the skin of the early embryo.
• The functional cooperation between MITF and the lymphoid enhancing factor ( LEF-1 ) results in a synergistic transactivation of the dopachrome tautomerase gene promoter, which is an early melanoblast marker.