micronucleus test การใช้

• Homozygous mutant animals displayed increased chromosomal stability in a micronucleus test.
• In mice, these are not removed, which is the basis for the " in vivo " micronucleus test.
• Fewer than expected homozygous mutant mice survived until weaning and those that did survive displayed evidence of chomosomal instability in a micronucleus test.
• Twenty six tests were carried out on mutant mice and one significant abnormality was observed : chromosomal instability was detect by a micronucleus test.
• The major drawback of using micronucleus tests is that they cannot determine different types of chromosomal aberrations and can be influenced by the mitotic rate and proportion of cell death, skewing the results.
• Homozygous mutant animals were infertile, did not have a pinna reflex, had a moderate degree of hearing impairment, abnormal cornea morphology, lens morphology and cataracts, and displayed chromosomal instability in a micronucleus test.