micronucleus การใช้

• Homozygous mutant animals displayed increased chromosomal stability in a micronucleus test.
• The macronucleus begins as a copy of the micronucleus.
• They are unusual among eukaryotes in that reproduction involves a micronucleus and a macronucleus.
• The latter is generated from the micronucleus by amplification of the genome and heavy editing.
• The micronucleus serves as the germ line nucleus, but does not express its genes.
• Only the DNA in the micronucleus is passed on during sexual reproduction ( conjugation ).
• The diploid germline micronucleus is transcriptionally silent and only plays a role during sexual life stages.
• Ciliates contain two types of nuclei : somatic " macronucleus " and the germline " micronucleus ".
• Defects in DNA damage response can cause increased frequency of micronucleus formation and hence the occurrence of chromothripsis.
• The cell then divides transversally, and each new cell obtains a copy of the micronucleus and the macronucleus.
• Some studies have shown that in individuals over 70 years of age, micronucleus frequency increases in both sexes.
• Although the micronucleus model is appropriate, other factors are likely to contribute towards chromothripsis for various cancer genomes.
• Since micronucleus assays reflect chromosomal aberrations reliably and rapidly, they are extremely useful for a quick assessment of chromosomal damage.
• In mice, these are not removed, which is the basis for the " in vivo " micronucleus test.
• Fewer than expected homozygous mutant mice survived until weaning and those that did survive displayed evidence of chomosomal instability in a micronucleus test.
• The micronucleus is the generative, or germline nucleus, containing the genetic material that is passed along from one generation to the next.
• Twenty six tests were carried out on mutant mice and one significant abnormality was observed : chromosomal instability was detect by a micronucleus test.
• Based on the structure of a Micronucleus, or the function of a cell, it provides support in the central apparatus within the cell.
• Micronucleus assay systems are very economical, require much less skill in scoring that conventional metaphase tests, and are much faster than these conventional tests.
• The ciliated protozoan Tetrahymena is a useful research model for studying nuclear dimorphism; it maintains two distinct nuclear genomes, the micronucleus and the macronucleus.