mirnas การใช้

• MREs are sequences to which miRNAs bind and cause gene silencing.
• Some miRNAs also undergo methylation-associated silencing in cancer cells.
• These six highly conserved miRNAs are clustered on three separate chromosomes.
• Here, miRNAs can function as both oncogenes and tumor suppressors.
• The mechanism of action of miRNAs is the subject of active research.
• The main function of miRNAs is to down-regulate gene expression.
• This differs from other endogenous miRNAs exhibited hetero-silencing.
• Loss of PLEKHA7 disrupts miRNAs regulation, causing tumorigenic signaling and growth.
• SiRNA therapy targeting the miRNAs mentioned above is being investigated.
• Examples of altered gene expression include that of miRNAs.
• The first human disease associated with deregulaton of miRNAs was chronic lymphocytic leukemia.
• Recently it has been found that miRNAs regulate EPC biology and tumour angiogenesis.
• Specifically investigating post-transcriptional gene regulation mediated by microRNAs ( miRNAs ).
• Several applications of miRNAs as biomarkers and predictors of disease are given below.
• Two areas in particular that are receiving attention as surrogate markers include miRNAs.
• This illustrates that AMOs can be used to successfully inhibit cancers through miRNAs.
• These miRNAs also change the methylation of the histones in the viral genome.
• Some miRNAs are processed by Microprocessor only in the presence of specific cofactors.
• Uridylation of some animal miRNAs has been reported.
• miRNAs occasionally also cause promoter sites, which affects the expression of target genes.