osmosin การใช้

• It was introduced to the market in the early 1980s in Osmosin ( indomethacin ) and Acutrim ( phenylpropanolamine ), but unexpectedly severe issues with GI irritation and cases of GI perforation led to the withdrawal of Osmosin.
• It was introduced to the market in the early 1980s in Osmosin ( indomethacin ) and Acutrim ( phenylpropanolamine ), but unexpectedly severe issues with GI irritation and cases of GI perforation led to the withdrawal of Osmosin.
• Merck & Co . later developed the Controlled-Porosity Osmotic Pump ( CPOP ) with the intention of addressing some of the issues that led to Osmosin's withdrawal via a new approach to the final stage of the release mechanism.