polybasic การใช้

• They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle.
• The common polybasic domain in the C-tail of Gq-coupled receptors is necessary for the receptor-G protein preassembly.
• He used potentiometric titration to observe the differences in titration between strong and weak acids, as well as the behavior of polybasic acids.
• This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues.
• The BMP group of proteins is characterized by a polybasic proteolytic processing site, which is cleaved to produce a protein containing seven conserved cysteine residues.
• In the dark, the J? helix docks to the LOV2 domain and cages the polybasic tail to prevent its interaction with negatively charged PM-resident phosphoinositides.
• Furin-like proprotein convertases ( PPC ) are responsible for conversion of 50 kDa HJV to a 40 kDa protein with a truncated COOH-terminus, at a conserved polybasic RNRR site.
• For example, The C-terminus of M 3 muscarinic receptors is sufficient, and the six-amino-acid polybasic ( KKKRRK ) domain in the C-terminus is necessary for its preassembly with G q proteins.
• The ER luminal domain of LiMETER contains a signal peptide and the transmembrane domain derived from STIM1, with Avena sativa phototropin 1, followed by a C-terminal PM-targeting polybasic tail that associates with negative charged phosphoinositides in the inner half of the leaflet of plasma membrane.
• Following blue light illumination, photoexcitation generates a covalent adduct between a cysteine residue and the flavin cofactor in LOV2, and subsequently promotes the undocking and unwinding of the J? helix, thereby exposing the polybasic C-tail to enable translocation of the protein towards PM to form puncta-like structures.