pregnenolone การใช้

• The conversion of pregnenolone to progesterone takes place in two steps.
• ACTH stimulates uptake of cholesterol and synthesis of pregnenolone.
• To assay conversion of cholesterol to pregnenolone, radiolabelled cholesterol has been used.
• Progesterone is prepared by the Oppenauer oxidation of pregnenolone.
• It is formed from pregnenolone in the adrenal glands.
• Pregnenolone product can be separated from cholesterol substrate using Sephadex LH-20 minicolumns.
• In addition to allopregnanolone, exogenous pregnenolone also functions as a prohormone of pregnenolone sulfate.
• In addition to allopregnanolone, exogenous pregnenolone also functions as a prohormone of pregnenolone sulfate.
• The products range from sugar-free maple syrup to capsules of the steroid hormone pregnenolone.
• In the human, the fetal adrenals produce dehydroepiandrosterone ( DHEA ) via the pregnenolone pathway.
• Pregnenolone is involved in a natural negative feedback loop against cannabis, from fully activating the CB 1
• Pregnenolone is then converted to progesterone that is secreted out of the cell and into the blood stream.
• This vicinal diol is then further oxidized with loss of the side chain starting at position C22 to produce pregnenolone.
• Lipoid CAH is one of the rarer forms of CAH and results from defects in the steps from cholesterol to pregnenolone.
• Pregnenolone stands poised to help fortify aging baby boomers in their quest to reclaim and sustain a sense of vitality and well-being.
• Fetal adrenal glands also produce pregnenolone in some species, which is converted into progesterone and estrogens by the placenta ( see below ).
• It catalyzes hydroxylation of 17?-hydroxyprogesterone to 11-deoxycortisol in the glucocorticoid pathway, which starts from pregnenolone and finishes with cortisol.
• It also catalyzes hydroxylation of progesterone to 11-deoxycorticosterone ( DOC ) in the mineralocorticoid pathway on its way from pregnenolone to aldosterone.
• Corticosterone has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone.
• Sripada et al . reported that oral pregnenolone is preferentially metabolized into the neurosteroid allopregnanolone rather than into other steroids such as DHEA or cortisol.