rofecoxib การใช้

• Overall, there was no safety superiority of rofecoxib over naproxen,
• Worldwide, over 80 million people were prescribed rofecoxib at some time.
• Notwithstanding these recommendations, Merck has not returned rofecoxib to the market.
• This led to the withdrawal of rofecoxib and valdecoxib, and warnings on others.
• Rofecoxib ( brand name Vioxx ) was withdrawn in 2004 because of such concerns.
• Several very large observational studies have also found elevated risk of heart attack from rofecoxib.
• One-third were given naproxen, one-third rofecoxib and one-third placebo.
• A statistically significant increase in the incidence of myocardial infarctions was observed in patients on rofecoxib.
• Rofecoxib was one of the most widely used drugs ever to be withdrawn from the market.
• Rofecoxib gained widespread acceptance among physicians treating patients with arthritis and other conditions causing chronic or acute pain.
• After the withdrawal of rofecoxib from the market in September 2004, Celebrex enjoyed a robust increase in sales.
• Graham's study concluded that Vioxx, also known as rofecoxib, had a dangerous effect on the heart.
• Rofecoxib ( Vioxx ) was shown to produce significantly fewer gastrointestinal adverse drug reactions ( ADRs ) compared with naproxen.
• The COX-2 inhibitor rofecoxib ( Vioxx ) was removed from the market in 2004 due to its risk.
• Other COX-2-selective inhibitors, such as rofecoxib, have significantly higher myocardial infarction rates than celecoxib.
• Parecoxib is a COX2 selective inhibitor in the same category as celecoxib ( Celebrex ) and rofecoxib ( Vioxx ).
• Celecoxib and rofecoxib, the first COX-2 inhibitors to reach market, were based on DuP-697.
• The study found that high doses of Vioxx, known as rofecoxib, tripled risks of heart attacks and sudden cardiac death.
• After 12 months of treatment, both the rofecoxib and naproxen groups showed cognitive declines similar to those found in the placebo group.
• Unlike ibuprofen, other painkillers _ acetaminophen, rofecoxib, diclofenac _ did not interfere with aspirin because the molecules have a different structure.