sandimmune การใช้

• Neoral is a new formulation of Novartis'Sandimmune.
• NeuroSTAT was recently compared to Sandimmune in a phase I study and found to be bioequivalent.
• Like tacrolimus, ciclosporin ( Novartis'Sandimmune ) is a calcineurin inhibitor ( CNI ).
• The biggest problem is the lack of drugs such as Sandimmune, made by the Swiss company Sandoz.
• Together, Sandimmune and Neoral have estimated worldwide sales of more than $ 1.2 billion a year.
• Novartis'Neoral is the newest version of its Sandimmune, which together have combined worldwide sales of $ 1.2 billion, Sangstat said.
• The biggest drugmaker after Glaxo Wellcome Plc, Novartis'best-selling drug is Sandimmune / Neoral, which is used in transplant surgery to lessen rejection.
• Iraq needs 15, 000 bottles a year of Sandimmune, or an equivalent, but the government says it has been able to get only 5, 000.
• Neoral and Sandimmune help reduce the pain and improve the functioning of patients by blocking the action of cells that cause swelling in the joints, company officials said today.
• Neoral's main side effects are similar to Sandimmune's-- gastrointestinal problems, headache, high blood pressure and, in some patients, kidney problems.
• Sandoz, whose scientists concocted the now-illegal psychedelic drug LSD during the 1950s, is best known for its Sandimmune transplant medicine and the Gerber line of baby foods.
• Haider Mahdi, recent recipient of a kidney transplant, rises slowly from his hospital bed and clutches a bottle of Sandimmune, an anti-rejection drug that helps keep him alive.
• In one study presented today, Novartis found methotrexate alone greatly improved the condition of 39 percent of patients, while Sandimmune alone reached the same level of improvement in 25 percent of patients.
• If approved, Sangstat's drug would be the first generic alternative to cyclosporine, which had worldwide sales of $ 1.2 billion for Sandoz last year, primarily under the trade name Sandimmune.
• Ciclosporin was originally brought to market by Sandoz, now Novartis, under the brand name Sandimmune, which is available as soft gelatin capsules, as an oral solution, and as a formulation for intravenous administration.
• The Iraqi government claims thousands of people are dying each month due to the lack of medical supplies, including drugs such as Sandimmune, which suppresses the immune system and prevents kidney patients from rejecting the transplanted organ.
• In another study of patients who didn't respond as well to methotrexate, the company found adding Sandimmune to methotrexate resulted in 43 percent of patients achieving a high level of improvement compared to 14 percent of patients who took a placebo plus methotrexate.
• The main difference between Sandimmune and Neoral is that the newer formulation is more " bioavailable, " meaning the drug achieves higher concentrations in a patient's blood, said Michael Perry, vice president for drug registration and regulatory affairs for Novartis.
• Pouletty said the FDA's finding of therapeutic equivalence meant that patients would not need a new prescription from their physician to switch from Neoral to Sangcya, and he noted that more than 70 percent of transplant patients had already switched from Novartis'older Sandimmune to Neoral.
• The handful of drugs now known to be involved include some common and potent ones, among them Plendil ( felodipine ) for high blood pressure and heart disease, Seldane ( terfenadine ) for allergies, Sandimmune ( cyclosporine ) to prevent rejection of transplanted organs, and Invirase ( saquinavir ) for treating AIDS.