selectins การใช้

• Selectins are part of the broader family of cell adhesion molecules.
• The selectins and selectin ligands determine the organ selectivity of metastasis.
• Selectins are adhesion molecules that facilitate the capture of circulating leukocytes.
• Suppressed expression of some selectins results in a slower immune response.
• Experimental research has targeted adhesion molecules known as selectins on epithelial cells.
• Thus, selectins may someday be essential to a regenerative therapy for osteoporosis.
• Cancer cells are able to infiltrate the in鸻mmatory system by interacting with selectins.
• The major classes are named integrins, Ig superfamily members, cadherins, and selectins.
• This glycoprotein provides selectins with carbohydrate ligands.
• Selectins are cell adhesion molecules that play an important role in the initiation of inflammatory processes.
• However, the initial interaction between selectins and cancer cells are not sufficient to confer metastasis.
• Colchicine diminishes neutrophil adhesion by decreasing expression of selectins, a family of cell adhesion molecules.
• :While all selectins contain the sushi domain, not all sushi domain containing proteins are selectins.
• :While all selectins contain the sushi domain, not all sushi domain containing proteins are selectins.
• Interestingly, the cytoplasmic and transmembrane domains are highly conserved between species, but not conserved across the selectins.
• On the neutrophil these are : L selectins, and on the endothelial cell : P and E selectins.
• On the neutrophil these are : L selectins, and on the endothelial cell : P and E selectins.
• Sialyl-Lewis x is a necessary partner for the three selectins that bind the leukocyte and endothelial cells.
• Cell surface expression of LAMP1 can serve as a ligand for selectins and help mediate cell-cell adhesion.
• There are three types of selectins found in humans; L-selectin, P-selectin and E-selectin.