sulfamethoxazole การใช้

• The mean serum half-life of sulfamethoxazole is 10 hours.
• Sulfamethoxazole is primarily renally excreted via glomerular filtration and tubular secretion.
• Sulfamethoxazole is metabolized in the human liver to at least 5 metabolites.
• Drug of choice is Trimethoprim / sulfamethoxazole, pentamidine, or dapsone.
• It consists of one part trimethoprim to five parts sulfamethoxazole.
• Trimethoprim / sulfamethoxazole and ampicillin are ineffective against " Campylobacter ".
• Sulfamethoxazole is contraindicated in people with a known hypersensitivity to trimethoprim or sulfonamides.
• Sulfamethoxazole is well-absorbed when administered topically.
• Prevention of Pneumocystis pneumonia using trimethoprim / sulfamethoxazole is useful in those who are immunocompromised.
• Trimethoprim / sulfamethoxazole should not be taken by anyone with a history of sulfa allergy.
• In vitro studies suggest sulfamethoxazole is not a substrate of the P-glycoprotein transporter.
• Sulfamethoxazole is also excreted in human milk.
• It is variably susceptible to tetracyclines, chloramphenicol, trimethoprim-sulfamethoxazole, and colistin.
• Regardless, trimethoprim and sulfamethoxazole in combination has been used as an antibacterial agent for decades.
• Spironolactone together with trimethoprim / sulfamethoxazole increases the likelihood of hyperkalemia, especially in the elderly.
• Trimethoprim-sulfamethoxazole, vancomycin, and fluoroquinolones can be used in cases of allergy to penicillin.
• Sensitivity, as of 2003, is still found in trimethoprim-sulfamethoxazole, vancomycin and bacitracin.
• Trimethoprim-sulfamethoxazole and doxycycline are no longer recommended because of high levels of resistance to these agents.
• Oral trimethoprim / sulfamethoxazole is an appropriate choice for therapy if the uropathogen is known to be susceptible.
• Sulfamethoxazole-trimethoprim : A potential drug interaction exists with concomitant use of sulfamethoxazole-trimethoprim and folinic acid.