sulfanilamide การใช้

• The company tested the new product, Elixir Sulfanilamide, for viscosity, appearance and fragrance.
• (UNDATED ) Sulfanilamide was a breakthrough drug in the 1930s, a life-saving antibiotic.
• The sulfanilamide compound is more active in the protonated form . 3 ( + ) is the protonated form?
• In 1937, a drug known as " Elixir Sulfanilamide " was released without any clinical trials.
• He finally saw a successful diagnosis and course of treatment, using sulfanilamide during his ten weeks at Massachusetts General.
• The first was chlorothiazide, the first thiazide diuretic and developed from the antibiotic sulfanilamide, which became available in 1958.
• Shortly after their wedding Forbes contracted pneumonia and was saved, in part, through the use of the drug sulfanilamide.
• In 1937 over 100 people died after ingesting " Elixir Sulfanilamide " manufactured by S . E . Massengill Company of Tennessee.
• There are contradictory accounts concerning whether sulfanilamides were given, but Gebhardt testified at his 1947 war crimes trial that they were not.
• Genzken was also accused of involvement in sulfanilamide experiments, poison experiments, and incendiary bomb experiments but was not convicted on these counts.
• In medicine, the term " sulfonamide " is sometimes used as a synonym for sulfa drug, a derivative or variation of sulfanilamide.
• Since the sulfanilamide moiety was also easy to link into other molecules, chemists soon gave rise to hundreds of second-generation sulfonamide drugs.
• His pioneering observation that the antibiotic sulfanilamide increased excretion of sodium in patients with heart failure led to the discovery and development of modern diuretic drugs.
• During her second year, Geiling was retained by the FDA to research unusual deaths related to elixir sulfanilamide, a congenital malformations ( birth defects ).
• This and nonexistent testing requirements led to the elixir sulfanilamide disaster in the fall of 1937, during which at least 100 people were poisoned with diethylene glycol.
• Likewise, prontosil, the first sulfa drug ( discovered by Gerhard Domagk in 1932 ), must be cleaved in the body to release the active molecule, sulfanilamide.
• In 1937, S . E . Massengill Co . ( a Tennessee drug company ), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug.
• The introduction of this act was influenced by the death of more than 100 patients due to a sulfanilamide medication where diethylene glycol was used to dissolve the drug and make a liquid form.
• Many thousands of molecules containing the sulfanilamide structure have been created since its discovery ( by one account, over 5, 400 permutations by 1945 ), yielding improved formulations with greater effectiveness and less toxicity.
• In 1937, S . E . Massengill Company, a pharmaceutical manufacturer, created a preparation of sulfanilamide using diethylene glycol ( DEG ) as a solvent, and called the preparation " Elixir Sulfanilamide ".