sulfatase การใช้

• The transformation of estrone sulfate to estrone is catalyzed by estrone sulfatase.
• It has also been used with the steroid sulfatase gene.
• Cys Subs = substrate protein cysteine embedded in sulfatase motif.
• Worldwide, forty cases of Multiple Sulfatase Deficiency have been reported to date.
• N-acetylglucosamine-6-sulfatase is a lysosomal enzyme found in all cells.
• Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
• The Sts gene encodes the steroid sulfatase enzyme, which is pivotal in the regulation of neurosteroid biosynthesis.
• A set of organisms from all domains of life was chosen and the sequence homology of the sulfatase motif was determined.
• Caused by the deficient enzyme N-acetylgalactosamine 4-sulfatase, Maroteaux Lamy syndrome has a variable spectrum of severe symptoms.
• These sulfatase enzymes are responsible for breaking down and recycling complex sulfate-containing sugars from lipids and mucopolysaccharides within the lysosome.
• Arylsulfatase E is a member of the arylsulfatase subfamily of sulfatase enzymes that catalyze the hydrolysis of glycosylated postranslationally and localized to the golgi apparatus.
• Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase.
• Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase.
• They further investigated the role of steroid sulfatases in metachromatic leukodystrophy and multiple sulfatase deficiency, and they identified acid ceramidase as the enzyme deficient in Farber s disease.
• Steroid sulfatase is distributed in a wide range of tissues throughout the body, enabling sulfated steroids synthesized in the adrenals and gonads to be desulfated following distribution through the circulation system.
• Genetic defects in sulfatase activity can arise through mutations in individual sulfatases and result in certain lysosomal storage disorders with a spectrum of phenotypes ranging from defects in physical and intellectual development.
• Multiple sulfatase deficiency is thought to be caused by any mutation of the SUMF1 gene which would render its protein product, the formylglycine-generating enzyme ( FGE ), defective.
• In mice, candidate genes for differentiating aggression between the sexes are the Sry ( sex determining region Y ) gene, located on the Y chromosome and the Sts ( steroid sulfatase ) gene.
• These abnormalities are now known to accompany X-linked ichthyosis, steroid sulfatase deficiency, caused by steroid sulfatase gene mutations and are currently usually not included under the rubric of the corneal dystrophies.
• These abnormalities are now known to accompany X-linked ichthyosis, steroid sulfatase deficiency, caused by steroid sulfatase gene mutations and are currently usually not included under the rubric of the corneal dystrophies.