thioaldehyde การใช้

• A thioaldehyde and a hydroperoxy ligand are produced in this process.
• The formation of 3-thiazolines also occurs by using ?-thioaldehyde or ?-thioketone and ammonia.
• The hydroperoxy ligand deprotonates the amide which then closes the ?-lactam ring by a nucleophilic attack at the thioaldehyde carbon.
• The equilibrium lies far to the product side due to the high reactivity of the thioaldehyde "'IV "'compared to the aldehyde "'VI "'and its arising tendency to form the hydrate "'V " '.
• The hydroxyl group is transferred to the substrate and a substrate-sulfenic acid "'III "'is generated . ? elimination of water leads to a thioaldehyde "'IV "'which is quickly hydrated to "'V "'and after elimination of H 2 S, the aldehyde "'VI "'is formed.