thrombin การใช้

• Direct thrombin inhibitors provides an excellent example of negative allosteric modulation.
• Thrombin also promotes secondary fibrin-reinforcement of the platelet plug.
• Each molecule of Factor Xa can generate 1000 molecules of thrombin.
• It therefore remains active and increases the rate of thrombin generation.
• Thrombin is a potent platelet activator, acting through Gq and G12.
• Excess circulating thrombin results from the excess activation of the coagulation cascade.
• Recombinant thrombin is available as a powder for reconstitution into aqueous solution.
• It functions as an inhibitor of coagulation by inhibiting thrombin.
• Inactivation of Factor V a thus practically halts the production of thrombin.
• Several other direct thrombin inhibitors are derived chemically from hirudin.
• In contrast to heparin, fondaparinux does not inhibit thrombin.
• Thrombin activates Factor V by cleaving off the B domain.
• Inhibition of Factor Xa prevents thrombin activation, thereby preventing clot formation.
• Normal values for thrombin time are 12 to 14 seconds.
• It is activated by trypsin, but not by thrombin.
• The fibrin sealants are made of two blood proteins, thrombin and fibrinogen.
• A . The bleeding causes the generation of thrombin, a clotting factor.
• Thrombin is implicated in the physiology of blood clots.
• Thrombin signalling in platelets contributes to hemostasis and thrombosis.
• Hirudin is the most potent natural inhibitor of thrombin.