transactivation การใช้

• In contrast, Myc contains a transactivation domain but cannot homodimerize.
• :See the basic definitions at Transactivation and transcription factor.
• UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains.
• This mechanism of action is referred to as transactivation.
• Acetyltransferases CBP and p300 bind to the transactivation domain.
• Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.
• MTA2 deacetylates the estrogen receptor alpha and p53 and inhibits their transactivation functions.
• Acetylation of BMAL1 recruits CRY1 to suppress the transactivation of CLOCK / BMAL1.
• Max itself lacks a transactivation domain so that Max homodimers have a repressive function.
• Hence the anti-inflammatory effects of glucocorticoids results from both transactivation and transrepression.
• AF1 is ligand-independent and plays the primary role in target gene transactivation.
• The molecule has two domains; the transactivation domain and the chromatin-remodeling domain.
• This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity.
• Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.
• Furthermore, many viruses express p53 inhibitors that can bind p53 and inhibit its transcriptional transactivation activity.
• This positive feedback loop leads to HIF-1 transactivation and an amplified effect on glucose metabolism.
• NFKBIE is able to inhibit NF-?B-directed transactivation via cytoplasmic retention of REL proteins.
• The resulting activated form GR has two principal mechanisms of action, transactivation and transrepression, described below.
• In activators, E2F binding with pRB has been shown to mask the transactivation domain responsible for transcription activation.
• The mRNA transcript is approximately 1.5 kilobases in length, and the 37.7 transactivation domain.