tropocollagen การใช้

• Three polypeptides coil to form tropocollagen.
• The two collagenases act synergistically by cleaving tropocollagen ( the'collagen molecule') at different points.
• If collagen is subject to sufficient denaturation, e . g . by heating, the three tropocollagen strands separate partially or completely into globular domains, containing a different secondary structure to the normal collagen polyproline II ( PPII ), e . g . random coils.
• In bone, entire collagen triple helices lie in a parallel, staggered array . 40 nm gaps between the ends of the tropocollagen subunits ( approximately equal to the gap region ) probably serve as nucleation sites for the deposition of long, hard, fine crystals of the mineral component, which is ( approximately ) Ca 10 ( OH ) 2 ( PO 4 ) 6.