tropoelastin การใช้

• Tropoelastin aggregates at physiological temperature due to interactions between hydrophobic domains.
• There are 36 small domains in Tropoelastin and each weighs about 2 kilodaltons.
• Tropoelastin is unusual in that it exists in multiple forms, called polymorphs.
• Tropoelastin confers strength and elasticity to the skin and other organs in the body.
• Amorphous elastin forms from monomers of soluble tropoelastin which is insolubilized and crosslinked into amorphous elastin by lysyl oxidase.
• Tropoelastin does not undergo cleavage and formation of the microfibril is achieved by a self-association process termed coacervation.
• It interacts with and inhibits the catalytic activity of LOX, preventing the crosslink of tropoelastin molecules into mature insoluble elastin.
• A synthetic form of human tropoelastin is made by DermaPlus Products from genetically modified organisms for use in wound healing and topical skin care.
• The association with these matrix structures is mediated by its ability to interact with numerous extracellular matrix constituents including fibronectin, proteoglycans, laminins and tropoelastin.
• They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans, and they participate in diverse supramolecular structures.
• Tropoelastin is not normally available in its native state, since it becomes crosslinked immediately after its synthesis by the cell and during its export into the extracellular matrix.