tumorigenicity การใช้

• The phenotypic result was loss of tumorigenicity of the CSCs and improved mouse survival.
• Researchers found that addition of DCC to an immortalized cell line suppressed tumorigenicity rather definitively.
• Tumor suppressors, however, also inhibit metastasis, since metastasis is dependent upon tumorigenicity.
• This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice.
• The researchers did not identify any signs of hyperproliferation, tumorigenicity, or ectopic tissue formation in either patient.
• In addition, the degradation products may have downstream effects as well that can increase cancer cell tumorigenicity and can serve as potential biomarkers.
• Myricetin reduces the risk of skin tumorigenicity that is caused by polycyclic aromatic hydrocarbons like benzo ( a ) pyrene, a highly carcinogenic compound.
• By blocking the MCT-1 activity this could inhibit the SHC signaling cascase and the oncogenicty and tumorigenicity that is regulated by SHC expression.
• Specifically, these results revealed that the serine-arginine-rich protein involved in the RNA splicing process, could suppress pancreatic cell tumorigenicity.
• Carcinogenesis, Mutagenesis, Impairment of Fertility : Long-term ( 2-year ) oral studies conducted in rats with erythromycin base did not provide evidence of tumorigenicity.
• Many of the mutations observed in cancer occur in the extracellular domain of PTPrho, suggesting that defective cell-cell aggregation may contribute to the tumorigenicity of these mutations.
• When colon cancer cells are engineered to express a mutant form of paxillin that is incapable of being tyrosine phosphorylated, the paxillin Y88F mutant, these cells exhibit reduced tumorigenicity.
• Aberrant overexpression of AKT1, which is observed in several cancers including breast, lung and prostate, results in reduced production of MDC1 and subsequently a destabilization of the genome and increased tumorigenicity.
• Overexpression of AGK sustains constitutive JAK2 / STAT3 activation, consequently promoting the cancer stem cell population and augmenting the tumorigenicity of esophageal squamous cell carcinoma ( ESCC ) cells both in vivo and in vitro.
• Expression of the variants of PTPkappa with mutations in the phosphatase domains, however, increased cell proliferation, migration and invasion, supporting a role for the involvement of the mutated variants of PTPkappa in tumorigenicity.
• Later, mice experiments by Halachmi and Witz showed that for the same cancer cell line, greater tumorigenicity was evident " in vivo " than the same strain inoculated " in vitro ".
• Ectopic expression of JDP2 inhibits the retinoic acid-induced differentiation of F9 cells By contrast, JDP2 induces terminal muscle cell differentiation in C2 myoblasts and reduces the tumorigenicity of rhabdomyosarcoma cells and restored their ability to differentiate into myotubes.
• A recent study suggested that SON may be a novel therapeutic molecular target for pancreatic cancer as the results of a recent study show that this protein is very important as far as proliferation, survival and tumorigenicity of cancer cells are concerned.
• "' Naoto T Ueno "'( born March 29, 1964 ) is a Professor of Medicine at The University of Texas MD Anderson Cancer Center; his research is in the area of inflammatory breast cancer and the molecular mechanism of metastasis and tumorigenicity.
• RPN2 silencing has been reported to repress tumorigenicity and to sensitize the tumors to cisplatin treatment, which led to the longer survival of NSCLC-bearing mice, suggesting that RPN2 may represent a promising new target for RNAi-based medicine against NSCLC . RPN2 is also reported to be one of the prothrombin-binding proteins on monocyte surfaces, suggesting that its involvement in the pathophysiology of thrombosis in patients with APS.