desmin การใช้
- In cardiac muscle, desmin is present in ?B-crystallin.
- The presence of desmin and myogenin can be detected using immunohistochemistry.
- Desmin is a 53.5 kD protein composed of 470 amino acids.
- Desmin is a subunit of intermediate filaments in cardiac muscle, skeletal muscle and smooth muscle tissue.
- Activated satellite cells also begin expressing muscle-specific filament proteins such as desmin as they differentiate.
- Desmin has been evaluated for role in assessing the depth of invasion of urothelial carcinoma in TURBT specimens.
- Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites.
- Later, a yeast two-hybrid method was used to demonstrate that syncoilin is a binding partner of desmin.
- LAM cells stain positively for smooth muscle actin, vimentin, desmin, and, often, estrogen and progesterone receptors.
- Desmin protein may also bind to the DAG complex, and regions of it are known to be involved in signaling.
- Staining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, S-100.
- It is classified by gene structure and coding sequence as a type III IF protein because of its homology with vimentin, GFAP and desmin.
- In adult muscle, desmin forms a scaffold around the Z-disk of the sarcomere and connects the Z-disk to the subsarcolemmal cytoskeleton.
- Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.
- The condition now called Desmin-related myofibrillar myopathy ( also called myofibrillar myopathy-1 ) was formerly called inclusion body myopathy 1 ( IBM1 ).
- Diagnosis may be aided by immunostaining; endometrial stromal nodules are positive for CD10; leiomyomas are positive for caldesmon and desmin ( and sometimes CD10 ).
- A separate study examined this in more detail in cardiac tissue and found that murine hearts lacking desmin developed hypertrophic cardiomyopathy and chamber dilation combined with systolic dysfunction.
- There are three major domains to the desmin protein : a conserved alpha helix rod, a variable non alpha helix head, and a carboxy-terminal tail.
- Since desmin links the mitochondria to the sarcomere it may transmit information about contractions and energy need and through this regulate the aerobic respiration rate of the muscle cell.
- On immunohistochemistry, these cells have trilinear coexpression including the epithelial marker cytokeratin, the mesenchymal markers desmin and vimentin, and the neuronal marker neuron-specific enolase.
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