hydroxytryptamine การใช้

• In May 1949, the structure of serotonin was discovered to be 5-hydroxytryptamine ( 5-HT ).
• Serotonin ( 5-hydroxytryptamine or 5-HT ), is a neurotransmitter found in the central and peripheral nervous systems.
• When done with neurotransmitters; epinephrine, nor-epinephrine, serotonin, and 5-hydroxytryptamine there was a relationship with personality traits.
• A decarboxylase with cofactor pyridoxal phosphate ( PLP ) removes CO 2 from 5-hydroxy-L-tryptophan to produce 5-hydroxytryptamine.
• Protonation of the amine from tryptophan restores the aromaticity of the pyridine ring and then imine is hydrolyzed to produce 5-hydroxytryptamine and PLP.
• Paroxetine is the most potent and one of the most specific selective serotonin ( 5-hydroxytryptamine, 5-HT ) reuptake inhibitors ( SSRIs ).
• From a neurobiological perspective, central serotonin ( 5-hydroxytryptamine, 5-HT ) neurotransmission has been shown to modulate both alcohol consumption and impulsivity.
• Serotonin ( 5-hydroxytryptamine ) is a monoamine neurotransmitter that plays a role in mood, eating, sleeping, arousal and potentially visual orientation processing.
• The neurotransmitter serotonin ( 5-hydroxytryptamine, 5-HT ) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects.
• In the biosynthesis of serotonin, the intermediate product is not tryptamine but 5-hydroxytryptophan, which is in turn decarboxylated to form 5-hydroxytryptamine ( serotonin ).
• This gene is a member of the family of human serotonin receptors, which are G protein-coupled receptors that stimulate cAMP production in response to serotonin ( 5-hydroxytryptamine ).
• The stings of some wasps, such as those of the " Polistes versicolor ", contain relatively large amounts of 5-hydroxytryptamine ( 5-HT ) in its venoms.
• The "'5-HT 2C receptor "'is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin ( 5-hydroxytryptamine, 5-HT ).
• The "'5-HT 1A receptor "'is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin ( 5-hydroxytryptamine, 5-HT ).
• The "'5-HT 6 receptor "'is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin ( 5-hydroxytryptamine, 5-HT ).
• In addition hypothalamic function is responsive to and regulated by levels of all three classical monoamine neurotransmitters, noradrenaline, dopamine, and serotonin ( 5-hydroxytryptamine ), in those tracts from which it receives innervation.
• It decreases metabolism of serotonin ( 5-hydroxytryptamine ) and certain other monoamines by inhibiting the activity of a family of enzymes called monoamine oxidases ( MAOs ), particularly type A ( MAO-A ).
• Tryptophan hydroxylases catalyze the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan ( 5-HTP ), which is subsequently decarboxylated to form the neurotransmitter serotonin ( 5-hydroxytryptamine or 5-HT ).
• In 1952, enteramine was shown to be the same substance as serotonin, and as the broad range of physiological roles was elucidated, the abbreviation 5-HT of the proper chemical name 5-hydroxytryptamine became the preferred name in the pharmacological field.
• It has been proposed that histidine residue His122 of serotonin N-acetyl transferase is the catalytic residue that deprotonates the primary amine of 5-hydroxytryptamine, which allows the lone pair on the amine to attack acetyl-CoA, forming a tetraherdral intermediate.