hydroxyprogesterone การใช้

• Progestins used for luteal support include dydrogesterone and 17?-hydroxyprogesterone caproate
• It is the 3-cyclopentyl enol ether of 17?-hydroxyprogesterone acetate.
• It can be synthesized from 17?-hydroxyprogesterone.
• In animals, it is approximately 25 times more potent than progesterone or hydroxyprogesterone caproate.
• Levels of 17?-hydroxyprogesterone, androstenedione, and cortisol may play a role in screening.
• It is a 17?-hydroxyprogesterone derivative and a derivative of the less potent chlormadinone acetate.
• One promising ester, [ 17?-hydroxyprogesterone acetate ], marketed as Prodox, was found.
• During the period of administration, the testosterone concentrations decreased and the serum 17?-hydroxyprogesterone concentrations increased.
• :progesterone + reduced ferredoxin + O 2 \ rightleftharpoons 15beta-hydroxyprogesterone + oxidized ferredoxin + H 2 O
• Medroxyprogesterone acetate ( Provera ) entered clinical use and became widely marketed, largely superseding the 17?-hydroxyprogesterone esters.
• In addition, whereas 9?-fluoro-11?-hydroxyprogesterone has pronounced mineralocorticoid effects, BKP lacks such effects.
• 17?-OHP is also the parent compound of a class of progestins referred to as the 17?-hydroxyprogesterone derivatives.
• "' Flumedroxone "'is a steroidal progestogen of the 17?-hydroxyprogesterone group that was never marketed.
• The human enzyme efficiently acts on progesterone, 17?-hydroxyprogesterone, androstenedione, and testosterone to 5?-reduced metabolites.
• Unlike many other 17?-hydroxyprogesterone derivatives but similarly to hydroxyprogesterone caproate, algestone acetophenide is reported to possess no glucocorticoid activity.
• Unlike many other 17?-hydroxyprogesterone derivatives but similarly to hydroxyprogesterone caproate, algestone acetophenide is reported to possess no glucocorticoid activity.
• Progesterone in turn is the precursor of the mineralocorticoid aldosterone, and after conversion to 17?-hydroxyprogesterone, of cortisol and androstenedione.
• Among others, this class of drugs includes chlormadinone acetate, cyproterone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, and megestrol acetate.
• "' Gestonorone caproate "'( synthetic, steroidal progestin of the 19-norprogesterone and 17?-hydroxyprogesterone groups.
• Clinical development of ethynerone was discontinued, and many of the 17?-hydroxyprogesterone derivatives were withdrawn for the indication of hormonal contraception.