hydroxysteroid การใช้

• This enzyme possesses the combined activities of the 20-?-hydroxysteroid dehydrogenase enzymes.
• These precursors are not further converted in the adrenal cortex if the cells lack 17Beta Hydroxysteroid dehydrogenase.
• 17beta-hydroxysteroid dehydrogenase 10 is a member of the short-chain dehydrogenase / reductase superfamily.
• In addition, the 3?-hydroxyl group is oxidized by 3?-hydroxysteroid dehydrogenase to produce androstenedione.
• The mechanism consists of an enzyme called 11 ?-hydroxysteroid dehydrogenase ( 11 ?-HSD ).
• The chemical shape of coumestrol orients its two inhibit the activity of aromatase and 3?-hydroxysteroid dehydrogenase.
• The systematic name of this enzyme class is "'16-hydroxysteroid 16-epimerase " '.
• Then, placental 17?-hydroxysteroid dehydrogenase interconverts estrone and estradiol and the two hormones are secreted into the maternal circulation.
• HSDL2 : Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide binding, oxidoreductase activity, and sterol binding.
• This may be due to limited activity topically because the skin lacks the necessary activating enzyme 11-Beta hydroxysteroid dehydrogenase.
• First, the 3?-hydroxyl group is oxidized to a 3?-hydroxysteroid dehydrogenase / ? 5-4-isomerase.
• In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17?-hydroxysteroid dehydrogenase to yield testosterone.
• The systematic name of this enzyme class is "'12alpha-hydroxysteroid : NADP + 12-oxidoreductase " '.
• :a steroid + reduced adrenal ferredoxin + O 2 \ rightleftharpoons an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H 2 O
• Isopregnanolone is intermediate in this two-step transformation ) and can be reversibly metabolized into allopregnanolone by the enzyme 3?-hydroxysteroid dehydrogenase.
• Inhibitory neurosteroids are biosynthesized by the action of two enzymes, 5?-reductase and 3?-hydroxysteroid dehydrogenase ( 3?-HSD ).
• He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3.
• This enzyme, 11-beta hydroxysteroid dehydrogenase type II ( Protein : HSD11B2 ), catalyzes the deactivation of glucocorticoids to 11-dehydro metabolites.
• Therefore, licorice should not be given to patients with a known history of hypertension in doses sufficient to inhibit 11-?-hydroxysteroid dehydrogenase.
• "' Trilostane "'is an inhibitor of 3?-hydroxysteroid dehydrogenase which is used in the treatment of Cushing's syndrome.