neprilysin การใช้

• A? is destroyed by several amyloid-degrading enzymes including neprilysin.
• There is also concern that neprilysin inhibition itself can potentiate angioedema.
• Mature AM is degraded by the aminopeptidase neprilysin.
• Neprilysin is expressed in a wide variety of tissues and is particularly abundant in kidney.
• There are enzymes, like one known as neprilysin, that appear to chew up amyloid, Mucke said.
• The encoded protein contains sequence and structural similarity to members of the neprilysin ( M13 ) family of zinc endopeptidases.
• Sacubitrilat inhibits the enzyme neprilysin, a neutral endopeptidase that degrades vasoactive peptides, including natriuretic peptides, bradykinin, and adrenomedullin.
• :: " Criticisms of Entresto center on the PARADIGM-HF trial having compared the combination neprilysin inhibitor and ARB valsartan to the ACE inhibitor enalapril rather than to valsartan alone.
• Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
• It also degrades the amyloid beta peptide whose abnormal membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface.
• Under normal physiology A? is cleared from the brain by four pathways : ( 1 ) endocytosis by astrocytes and microglial cells, ( 2 ) enzymatic degradation by neprilysin or blood brain barrier or ( 4 ) drained along periarterial spaces.
• Repressive hypermethylation caused by amyloid-beta has been observed at the promoter of " NEP ", the gene for neprilysin, which is the major amyloid-beta clearing enzyme in the brain ( Chen et al ., 2009 ).
• Some studies suggest that ACE inhibitors that are able to pass the blood-brain-barrier ( BBB ) could enhance the activity of major amyloid-beta peptide degrading enzymes like neprilysin in the brain resulting in a slower development of Alzheimer's disease.
• Earlier on, the ACE ( angiotensin-converting enzyme, EC 3.4 . 15.1 ), and the NEP ( neprilysin, EC 3.4 . 24.11 ), had been described, at the end of the 1960s, and in 1973, respectively.