oncofetal การใช้

• Oncofetal antigens are another important class of tumor antigens.
• Putative markers for lung CSCs have been reported, including CD133 +, ALDH +, CD44 + and oncofetal protein 5T4 +.
• It is the first aspartic protease present in the fetal stomach and is found in more than half of gastric cancers, leading to it appearing to be an oncofetal antigen.
• Elevated Hsp70 levels in tumor cells may increase malignancy and resistance to therapy by complexing, and hence, stabilizing, oncofetal proteins and products and transporting them into intracellular sites, thereby promoting tumor cell proliferation.
• It is an N-glycosylated transmembrane 72 kDa glycoprotein containing eight leucine-rich repeats . 5T4 is often referred to as an " oncofetal antigen " due to its expression in foetal trophoblast ( where it was first discovered ) or trophoblast glycoprotein ( TPBG ).