opsonization การใช้

• Opsonization also mediates phagocytosis via signal cascades from cell surface receptors.
• This mechanism of antibody-mediated increase in phagocytic efficacy is named opsonization.
• Opsonization of apoptotic cells occurs by different mechanisms in a tissue-dependent pattern.
• Phagocytic efficacy can be enhanced by opsonization.
• The coating of platelets with IgG renders them susceptible to opsonization and phagocytosis by receptor agonists.
• In all three pathways, C3-convertase cleaves and activates component phagocytic cells by opsonization.
• These immunoglobulins play a major role in destruction of the pathogen through mechanisms such as opsonization.
• :No . The spleen has a function, called opsonization, in the immune system.
• It binds to serum factor H, destroying C3-convertase and preventing opsonization by C3b.
• For targets to be recognized, they must be coated in opsonins a process known as antibody opsonization.
• Patients without spleens often need immunizations against pathogens that normally require opsonization and phagocytosis by macrophages in the spleen.
• Opsonization involves the binding of an opsonin, e . g ., antibody, to an epitope on an antigen.
• Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.
• M protein also inhibits opsonization by the alternative antibodies produced by the immune system against M protein target the bacteria for engulfment by phagocytes.
• The rationale for this approach is a presumed synergy between vancomycin, which causes the death of the bacteria by opsonization and phagocytosis ).
• This opsonization enhances the clearance of red blood cell by phagocytes in the liver, spleen, and lungs, a process termed extravascular hemolysis.
• By itself, IgM is an ineffective opsonin; however it contributes greatly to opsonization by activating complement and causing C3b to bind to the antigen.
• Activation of this system leads to cytolysis, chemotaxis, opsonization, immune clearance, and inflammation, as well as the marking of pathogens for phagocytosis.
• However plasma B cells can generate antibodies against M protein which will help in opsonization and further the destruction of the microorganism by the macrophages and neutrophils.
• CR3 has also been shown to mediate phagocytosis of the Lyme disease causing bacterium, " Borrelia burgdorferi ", in the absence of iC3b opsonization.