pgh2 การใช้

• PGH2 has a 5-carbon ring bridged by molecular oxygen.
• Thromboxane A ( TXA ) is derived from the prostaglandin H2 ( PGH2 ) molecule.
• This enzyme catalyses the synthesis of PGE2 from PGH2 ( produced by cyclooxygenase from arachidonic acid ).
• CYP4F12 also metabolizes prostaglandin H2 ( PGH2 ) and PGH1 to their corresponding 19-hydroxyl analogs in a reaction that might serve to reduce their activities.
• These metabolites contain two double bonds and are named series 2 prostanoids, i . e . PGD2, PGE2, PGF2?, PGI2, TXA2 and PGH2.
• This enzyme catalyzes the reduction of prostaglandin ( PG ) D2, PGH2 and phenanthrenequinone ( PQ ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2.
• PGH2 contains a relatively weak epidioxy bond, and a possible mechanism is known to involve homolytic cleavage of the epidioxide and a rearrangement to TXA . A heme group in the active site of TXA synthase plays an important role in the mechanism.
• The many other actions of 12 ( " S " )-HETE ( see 12-Hydroxyeicosatetraenoic acid ) and any other ligands found to interact with this receptor will require studies similar those conducted on PC3 cells and mesenteric arteries to determine the extent to which they interact with BLT2, TXA2 / PGH2, and PPARgamma receptors and thereby may contribute in part or whole to their activity.
• In addition, PGG2 and PGH2 rearrange non-enzymatically to a mixture of 12-Hydroxyheptadecatrienoic acids viz ., 1 2-( S )-hydroxy-5Z, 8E, 10E-heptadecatrienoic acid ( i . e . 12-HHT ) and 12-( S )-hydroxy-5Z, 8Z, 10E-heptadecatrienoic acid plus Malonyldialdehyde . and can be metabolized by CYP2S1 to 12-HHT ( see 12-Hydroxyheptadecatrienoic acid ).
• In addition to its ability to metabolize and presumably thereby to inactivate or reduce the activity of PGH2 and PGH1, CYP4F8 adds hydroxyl residues to carbons 18 and 19 of arachidonic acid and Dihomo-?-linolenic acid, CYP458 possesses epoxygenase activity in that it metabolizes the omega-3 fatty acids, docosahexaenoic acid ( DHA ) and eicosapentaenoic acid, ( EPA ) to their corresponding epoxides, the epoxydocosapentaenoic acids ( EDPs ) and epoxyeicosatetraenoic acids ( EEQs ), respectively.