self-antigen การใช้

• Autoantibodies can also recognize self - antigens already in tissues and generate immune complexes on - site
• Transplantation has been developed to an effctive strategy for treatment of end stage diseases of multiple organs since 1950 ' s . despite success of current immunosuppressive drugs , transplantation immunologists and surgeons are still seeking to achieve tolerance to allograft . there are several different mechanisms such as clonal deletion , anergy , neglect , immuno regulation . which maintain tolerance to self - antigen . some strategies , derived from these mechanisms has been proved to be encouraged in suppression of allograft rejection