transphosphorylation การใช้

• In the context of c-Raf, both c-Raf and KSR1 are needed for the " transphosphorylation " step.
• Kinase inhibitors are low molecular weight molecules that prevent ATP binding to MET, thus inhibiting receptor transphosphorylation and recruitment of the downstream effectors.
• The theoretical ErbB3 homodimer would be non-functional because the kinase-impaired protein requires transphosphorylation by its binding partner to be active.
• It has also been shown that Rho is not the only activator of ROCK . ROCK can also be regulated by lipids, in particular arachidonic acid, and protein oligomerization, which induces N-terminal transphosphorylation.
• These phosphorylation events are essential for the activity of the enzyme, and 3-phosphoinositide-dependent protein kinase-1 ( PDK1 ) is the upstream kinase responsible for initiating the process by transphosphorylation of the activation loop.