transpeptidases การใช้

• PBPs, also known as transpeptidases, are targets for beta-lactams.
• They interact with murein synthases as well as two transpeptidases ( PBP2 and PBP3 ).
• The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by DD-transpeptidases which are penicillin binding proteins ( PBPs ).
• Transpeptidases, such as the sortases responsible for anchoring factors like protein A to the staphylococcal peptidoglycan, are being studied in hopes of developing new antibiotics to target MRSA infections.
• The " mecA " gene does not allow the ringlike structure of penicillin-like antibiotics to bind to the enzymes that help form the cell wall of the bacterium ( transpeptidases ), and hence the bacteria is able to replicate as normal.
• The biosynthetic pathways of synthesis of ?-glutamylpeptides and alliins are still ambiguous . ?-Glutamylpeptides can be formed from cysteine ( via ?-glutamylcysteine or glutathione ) and can be metabolized into the corresponding alliins via oxidation and subsequent hydrolyzation by ?-glutamyl transpeptidases.