allopregnanolone การใช้

• Allopregnanolone, a neurosteroid, aids the continued neurogenesis in the brain.
• Other than progesterone, progestogens have several neuroactive metabolites, most notably allopregnanolone.
• Levels of allopregnanolone in the brain decline in old age and Alzheimer's disease.
• In addition to allopregnanolone, exogenous pregnenolone also functions as a prohormone of pregnenolone sulfate.
• The mPRs appear to be involved in the neuroprotective and antigonadotropic effects of progesterone and allopregnanolone.
• Also like progesterone, recent evidence has shown that allopregnanolone is an activator of the pregnane X receptor.
• Levels of isopregnanolone, progesterone, and allopregnanolone are highly correlated across the menstrual cycle and throughout pregnancy.
• Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression.
• The action of allopregnanolone at these receptors may be related, in part, to its neuroprotective and antigonadotropic properties.
• Fluoxetine increases the concentration of circulating allopregnanolone, a potent GABA A receptor positive allosteric modulator, in the brain.
• Norfluoxetine, a primary active metabolite of fluoxetine, produces a similar effect on allopregnanolone levels in the brains of mice.
• Allopregnanolone has been shown through reversing impairment of neurogenesis to reverse the cognitive deficits in a mouse model of Alzheimer's disease.
• In trials, both progesterone and allopregnanolone administration have shown a neuroprotective effect on hippocampal neurons in seizure models induced by kainic acid.
• It has been found that allopregnanolone, an effective mPR ligand, can act as an mPR agonist at low physiologically relevant concentrations.
• Acute stress elevates the levels of inhibitory neurosteroids like allopregnanolone, and these neurosteroids are known to counteract many of the effects of stress.
• Similarly to many other GABA A receptor positive allosteric modulators, allopregnanolone has been found to act as an Ca v 1.3.
• Isopregnanolone is intermediate in this two-step transformation ) and can be reversibly metabolized into allopregnanolone by the enzyme 3?-hydroxysteroid dehydrogenase.
• The concentrations of isopregnanolone are significantly less than those of progesterone and allopregnanolone; about half of those of allopregnanolone, to be precise.
• The concentrations of isopregnanolone are significantly less than those of progesterone and allopregnanolone; about half of those of allopregnanolone, to be precise.
• The neuroactive steroid allopregnanolone, made from progesterone, dampens the sensitivity of brain cells; it works like benzodiazepine drugs, most familiarly Valium.