allopurinol การใช้

• Allopurinol has rare but potentially fatal adverse effects involving the skin.
• Historically, heterozygous females were often diagnosed using an allopurinol challenge.
• Most affected individuals can be treated with allopurinol all through life.
• Both groups were then given a single dose of allopurinol.
• It is an active metabolite of allopurinol and it is cleared renally.
• He introduced the administration of allopurinol to lower mortality in cardiac surgery patients.
• Another side effect of allopurinol is interstitial nephritis.
• The active metabolite of allopurinol is oxypurinol, which is also an inhibitor of xanthine oxidase.
• For this reason, oxypurinol is believed responsible for the majority of allopurinol's effect.
• Allopurinol is used in dogs with altered purine metabolism to prevent the formation of uric acid.
• Allopurinol is taken orally, at a typical dose of 3 20 mg / kg per day.
• Moreover, allopurinol can also cause peripheral neuritis in some patients, although this is a rare side effect.
• Examples of slow-binding inhibitors include some important drugs, such methotrexate, allopurinol, and the activated form of acyclovir.
• Even children treated from birth with allopurinol develop behavioral and neurologic problems, despite never having had high serum concentrations of uric acid.
• Allopurinol is a drug that inhibits the enzyme xanthine oxidoreductase and, thus, lowers the level of uric acid in the body.
• It is a building block for many drugs, including dextromethorphan, amiloride, sulfadimethoxine, and allopurinol, and also for Peldesine.
• Today, inflammation during attacks is more commonly treated with NSAIDs, colchicine, or corticosteroids, and urate levels are managed with allopurinol.
• Because xanthine oxidase is a metabolic pathway for uric acid formation, the xanthine oxidase inhibitor allopurinol is used in the treatment of gout.
• Allopurinol is used to reduce urate / uric acid formation in conditions where urate / uric acid deposition has already occurred or is predictable.
• More rarely, allopurinol can also result in the depression of bone marrow elements, leading to cytopenias, as well as aplastic anemia.