enamine การใช้

• I wonder what significance the enamine motif comes into play.
• Enamines are considered to be nitrogen analogs of enols.
• The Stork enamine alkylation is named in his honor.
• The same chiral imidazolidinone organocatalyst was used to form enamine and introduce chirality.
• Proline enters a catalytic cycle by reacting with the aldehyde to form an enamine.
• The Tebbe reagent converts esters and lactones to enol ethers and amides to enamines.
• The enamine-imine tautomerism may be considered analogous to the keto-enol tautomerism.
• It is used to activate ketones and aldehydes toward nucleophilic addition by formation of enamines:
• The enamine eliminates sodium bisulfite with formation of naphthylamine "'6 " '.
• Such reactions proceed via enamine intermediates.
• They report that the catalyzing effect originates from enamine activation through a diketodienamine-ZnCl 2 complex.
• In this reaction proline catalyzes the reaction through creation of an enamine intermediate that is highly nucleophilic.
• LSD also has enamine-type reactivity because of the electron-donating effects of the indole ring.
• This reaction may be catalyzed by proline to proceed through chiral enamine intermediates which allow for good stereoselectivity.
• Conversion to other nitrogen-containing functionality, including enamines, imines, and amides, is also possible.
• Enamines chemistry has been implemented for the purposes of producing a one-pot enantioselective version of the Robinson annulation.
• The intermediate enamines are electronically related to push pull olefins, having an conjugated to an electron-donating group.
• An alkene C H bond activation with a rhodium catalyst is demonstrated in the synthesis of this strained bicyclic enamine:
• The imine then tautomerizes to an enamine, followed by cyclization, elimination of water, and isomerization to the pyrrole.
• An enamine transition state is formed during the reaction and only one proline molecule is involved in forming the transition state.