hydroxylysine การใช้

• This enzyme is involved in degrading the amino acids lysine, hydroxylysine and tryptophan.
• Glycosylation of hydroxylysine starts in the ER, but occurs predominantly in the Golgi apparatus.
• It was first discovered in 1921 by Donald Van Slyke as the 5-Hydroxylysine form.
• Thus, the two products are D-glucose and protein beta-D-galactosyl-L-hydroxylysine.
• Many lysines in collagen are hydroxylated to form hydroxylysine, and many of these hydroxylysines are then glycosylated by the addition of galactose.
• "' Hydroxylysine "'( Hyl ) is an amino acid with the molecular formula C 6 H 14 N 2 O 3.
• One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals.
• Mutations in the DHTKD1 gene are associated with alpha-aminoadipic and alpha-ketoadipic aciduria, an autosomal recessive inborn error of lysine, hydroxylysine, and tryptophan degradation.
• Seeds of the sweet pea contain beta-aminopropionitrile that prevents the cross-linking of collagen by inhibiting lysyl oxidase and thus the formation of hydroxylysine, leading to loose skin.
• Other names in common use include hydroxylysine galactosyltransferase, collagen galactosyltransferase, collagen hydroxylysyl galactosyltransferase, UDP galactose-collagen galactosyltransferase, uridine diphosphogalactose-collagen galactosyltransferase, and UDPgalactose : 5-hydroxylysine-collagen galactosyltransferase.
• Other names in common use include hydroxylysine galactosyltransferase, collagen galactosyltransferase, collagen hydroxylysyl galactosyltransferase, UDP galactose-collagen galactosyltransferase, uridine diphosphogalactose-collagen galactosyltransferase, and UDPgalactose : 5-hydroxylysine-collagen galactosyltransferase.
• The 80-amino acid helical component of each triple peptide contain many Gly-X-Y sequences, where X and Y are proline, isoleucine, or hydroxylysine; they, therefore, strongly resemble collagen fibrils.
• Two molecules of N-methyl asparagine are bound to the ? chain, one 5-hydroxylysine to ? (-3 or-2 ), one Mg 2 + to ?-3 and ?, one Cl  " to ?, 1-2 molecules of SO 4 2 " to ? or ?.